To decipher the mechanism of the increased amount of proline upon the activation of ADORA2A signaling, we compared the key genes of enzymes that catalyze the proline synthesis, including PYCR1, PYCR2, and PYCR3 (Figure 3D), between NEPC and ADPC using the Beltran PCa data set (24). The gene discussed is ADORA2A; the disease is posterior cortical atrophy.