To explore upstream regulators of PYCR1 and PYCR2 in NEPC, we performed ATAC-Seq on PCa organoids from a typical ADPC GEMM Pbsn-Cre4; Ptenfl/fl; Trp53fl/fl (PtenΔ/ΔTrp53Δ/Δ) and the NEPC Rb1Δ/ΔTrp53Δ/Δ mouse line. This evidence concerns the gene PYCR2 and posterior cortical atrophy.