Interestingly, in contrast to the prominent NE tumor phenotype in DKO prostates, TKO prostates displayed an evident expression of luminal cell markers CK8 and AR and a downregulation of the NE marker SYP (Figure 7, G and H), supporting a function of ADORA2A in modulating PCa cellular plasticity. The gene discussed is ADORA2A; the disease is neoplasm.