In addition, we examined several genetically engineered mouse models (GEMMs) of PCa, including the Pbsn-Cre4; Ptenfl/fl; Hi-Myc (MychiPtenΔ/Δ) (29), TRAMP (30), and Pbsn-Cre4; Rb1fl/fl; Trp53fl/fl (Rb1Δ/ΔTrp53Δ/Δ) (31), to assess ADORA2A expression patterns in these models. This evidence concerns the gene ADORA2A and posterior cortical atrophy.