To further explore the role of ADORA2A in SCLC, we infected the Rb1fl/fl; Trp53fl/fl and Adora2afl/fl; Rb1fl/fl; Trp53fl/fl mice with the Cre recombinase–expressing adenovirus (Adeno-Cre) through intratracheal injection (Figure 8A) to generate Adeno-DKO and Adeno-TKO lung tumors. This evidence concerns the gene ADORA2A and small cell lung carcinoma.