To decipher the mechanism of the increased amount of proline upon the activation of ADORA2A signaling, we compared the key genes of enzymes that catalyze the proline synthesis, including PYCR1, PYCR2, and PYCR3 (Figure 3D), between NEPC and ADPC using the Beltran PCa data set (24). This evidence concerns the gene PYCR3 and posterior cortical atrophy.