SELL and neoplasm: To summarize, inactivation of SOCS1 in transferred CD8+ T cells led to (a) enhanced accumulation in blood, spleen, TDLNs, and tumor; (b) increased accumulation as CD44+CD62L+ Tcm cells in the spleen and TDLNs, and (c) no impact on the frequency of Slamf+CD39–PD-1med Texprog cells while (d) markedly increasing the accumulation of Slamf–CD39+PD-1hi cells encompassing Texint, Texeff, and CD8 subsets.