Across 26 independent data sets and 15 donors, we consistently observed editing efficiencies of the SOCS1 gene of over 80% in KSQ-001 (Figure 6B), with editing of the SOCS1 gene resulting in complete depletion of SOCS1 protein in KSQ-001 manufactured from both NSCLC and melanoma donors (Figure 6C). This evidence concerns the gene SOCS1 and melanoma.