TAC1 and myeloid sarcoma: Consistent with literature demonstrating positive correlations between the number of adverse childhood experiences and poorer health outcomes (Felitti et al., 1998), the MS/mTBI groups had significantly elevated CGRP levels, while females in the MS injured groups had elevated levels of Substance P. CGRP and Substance P are released following a pain response, which results in vasodilation and inflammation, transmission of nociceptive information, and the perpetuation of pain responses (Durham, 2006, Graefe and Biochemistry, 2022).