TLR9 and HIV infectious disease: Signals conciliated by pathogens can activate HIV transcription via cytokines, induce cell factor expression, and activate viral long terminal repeats.[211]TLR2, TLR4, and TLR9 are associated with activating gene expression and viral replication during HIV infection and contribute to HIV severity through an antigenic group (Ag) and (5′‐Cytosine‐phosphate‐Guanine‐3′) CpG induction.[98, 99, 100, 101]TLR9 has been associated with modulating the extent of viral replication.