IL18 and COVID-19: The nuclear factor kappa B (NF‐κB) binding site polymorphism of the IL‐6 promoter (pIL6‐luc‐651ΔNF‐κB) eliminates the effect of the p65 and N proteins on IL‐6 promoter activation.[156, 157] In addition, IL‐18 correlates with severe COVID‐19 and thus plays a role in inflammasome activation and pyroptosis.[173]