IL‐6 and IL‐1 accumulate in the acute phase response.[137] Increased IL‐1β, IL‐4, and IL‐6 levels were associated with TBM, however, IL‐4 and IL‐6 levels were not significantly different between TBM and individuals without meningitis and CNS infection.[138] The effect of CD4+ T cell response makes IL‐6 crucial in the protection against murine M. tuberculosis infection.[151]IL‐6 deficiency resulted in an altered Th1 response and raised bacterial loads.[152] This indicates the importance of IL‐6 in the immune response against TB. This evidence concerns the gene CD4 and tuberculosis.