The CCL2 chemokine is involved in the migration of inflammatory monocytes. It is produced by alveolar macrophages, T cells, and endothelial cells. In addition, CCL2 chemokines were expressed at higher levels in lung macrophages of severe COVID‐19 patients. CCL2 was upregulated early post‐SARS‐CoV‐2 infection. This evidence concerns the gene CCL2 and COVID-19.