IFNA1 and COVID-19: Severe COVID‐19 is associated with sustained IFN response. Severe COVID‐19 patients had disrupted IFN‐α and β production and downregulation of IFN‐simulated genes. Mossel et al. did an in vitro study and showed that IFN‐α and IFN‐γ have a synergistic effect that inhibits SARS‐CoV replication.