The VDR gene is a transcription factor that controls the expression of various genes involved in physiological processes,[18] such as immunity and cell differentiation to target tissues.[19]VDR was suggested to be important in malaria, TB, HIV, and SARS‐Cov‐2 susceptibility and COVID‐19 severity in different populations.[14, 20, 21, 22] Polymorphisms within host genes, can alter the gene function and lead to anti or pro‐disease activity.[23, 24, 25, 26] Several common host genes and gene polymorphisms play a role in infectious diseases. The gene discussed is VDR; the disease is malaria.