CCL2 and meningeal tuberculosis: found an association between CCL2 SNP (rs4586), resulting in a T > C allele change, and pediatric TB in Han Chinese males, indicating that gender may affect TB susceptibility even in children.[69] The homozygous T genotype associated with reduced cerebrospinal fluid (CSF) and mononuclear leukocyte (ML) count suggests significance, and potential to assist with tuberculosis meningitis (TBM) assessment in serious cases.[69] This polymorphism is common among Africans, it might contribute to the high TB rates in Africa.