For instance, Davey et al. developed a seven mRNA biomarker model (FOLH1, HPN, CD24, TMPRSS2-ERG overexpressed; ITSN1, ANXA3, SLC45A3 underexpressed) that could distinguish PCa from benign conditions with AUC of 0.825. This evidence concerns the gene ITSN1 and posterior cortical atrophy.