CA9 and cancer: Importantly, the data from these models demonstrates that CAIX inhibition may sensitize tumour cells to cytotoxic drugs and evidence now points to ferroptosis, an iron-dependent form of regulated cell death (RCD) that results from accumulation of toxic levels of phospholipid peroxidation (Stockwell, 2022), as a major mechanism involved in CAIX-mediated sensitization to cancer therapy.