CDK1 and colorectal carcinoma: Several studies suggest that overexpression of CDK1, which is the hallmark event in many malignancies is associated with 5 = fluorouracil resistance through altered activation of Wnt/β-catechin signaling, mTOR, and p53 pathways leading to poor prognosis in CRC (Zhu et al., 2019; Zhu et al., 2020a; Zhu et al., 2020b; Sofi et al., 2022a).