PHB2 and liver dysplastic nodule: Furthermore, a study found that tumor necrosis factor alpha-induced protein 8-like 1 (TIPE1) regulates the ubiquitination and degradation of the mitochondrial autophagy receptor prohibitin 2, disrupting mitochondrial homeostasis, promoting the pathogenesis of diabetic nephropathy (DN), and demonstrating that inhibiting TIPE1 can serve as a novel therapeutic target for DN (Liu L. et al., 2022).