By enhancing hypoxia-inducible factor 1α (HIF1A) and BNIP3-mediated mitophagy, suppressing the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3) inflammasome alleviates pyroptosis in contrast-induced AKI(Lin et al., 2021). This evidence concerns the gene HIF1A and acute kidney injury.