In HFD/STZ-induced DN mice, activating the NLRP3 inflammasome worsens podocyte autophagy and decreases podocyte nephrin expression, while silencing NLRP3 effectively reverses podocyte autophagy and improves podocyte injury caused by high glucose levels (Hou et al., 2020). The gene discussed is NLRP3; the disease is liver dysplastic nodule.