Finally, it is also important to underscore the correlations observed between changes in functional parameters and MMP-7, a novel biomarker of ECM remodeling, included in the PROFILE (Prospective Study of Fibrosis in Lung Endpoints) study (Maher et al., 2017) as a measurement that may allow to follow the progression and the prognosis in IPF patients (Saini et al., 2012). Here, MMP7 is linked to fibrosis.