The inflammatory, TNF-α/NF-κB, as well as the KRAS pathways, were activated early during the transformation of normal to adenoma, and the IL-6/STAT3, angiogenesis, EMT, IL-2/STAT5, p53, and Wnt/β-catenin pathway were activated late during the transformation of adenoma to carcinoma. This evidence concerns the gene TP53 and adenoma.