HEXB and cerebellar ataxia: Most mice exhibited body tremors, ataxia and total significant weight loss (Supplementary Figure 3) by their humane endpoint, similar to Hexb−/− mice (Phaneuf et al., 1996), albeit with a slightly longer life expectancy (27 weeks versus 16 weeks) and milder symptoms in early disease stages (Huang et al., 1997; Wada et al., 2000; Toro et al., 2021).