SQSTM1 and Parkinson disease: Initially, we found that S-nitrosylation of SQSTM1/p62 (forming SNO-SQSTM1/p62) is significantly elevated in SH-SY5Y cells exposed to the physiological NO donor, S-nitrosocysteine (SNOC) or to a PD-related toxin, rotenone, which triggers neurotoxic production of RNS/NO.