Moreover, we find elevated levels of SNO-SQSTM1/p62 in human iPSC-derived A9-type dopaminergic neurons (designated hiPSC-DA neurons) bearing an A53T mutation in the SNCA gene, which causes a familial form of PD, when compared to isogenic, gene-corrected (wild-type [WT]) control hiPSC-DA neurons. The gene discussed is SNCA; the disease is Parkinson disease.