It inhibits cell proliferation and induces apoptosis and death in 17 primary glioma cell lines, 6 TMZ-resistant glioma cell lines, 4 neurospheres and 3 PDOs (135).Another research showed that by inducing mtUPR and the subsequent ROS burst, TRAP1 function was inhibited and GBM cells were sensitised to TMZ lysis after gamitrinib treatment (136). This evidence concerns the gene TRAP1 and central nervous system cancer.