Under unfavorable nutrient conditions such as nutrient deprivation or amino acid shortage, tumor cells are able to utilized mtHsp90-directed and TRAP1 directed protein folding (14) to maintain ATP production (6), thus attenuating the activation of the nutrient-sensing, tumor-suppressive AMPK pathway (80) and tumor cell autophagy pathway (6). The gene discussed is TRAP1; the disease is neoplasm.