TRAP1 and glioma: It inhibits cell proliferation and induces apoptosis and death in 17 primary glioma cell lines, 6 TMZ-resistant glioma cell lines, 4 neurospheres and 3 PDOs (135).Another research showed that by inducing mtUPR and the subsequent ROS burst, TRAP1 function was inhibited and GBM cells were sensitised to TMZ lysis after gamitrinib treatment (136).