TRAP1 and amyotrophic lateral sclerosis: In addition to its significant role in the development, metastasis, and maintenance of cancer, aberrant expression of TRAP1 has been associated with a number of diseases, including but not limited to the following: TRAP1 overexpression protects motor neurons from mitochondrial dysfunction and death under conditions of oxidative stress caused by amyotrophic lateral sclerosis (ALS) (110).