While the efficacy of inhibitors targeting the other Hsp90 protein, such as Ganetespib (STA-9090) and luminespib (AUY922), has been demonstrated in certain cancers, including hepatocellular carcinoma (HCC) (192), pancreatic cancer (PC) (193), gastric cancer (GC) (194, 195). Here, HSP90AA1 is linked to familial pancreatic carcinoma.