DESeq2 analysis between healthy controls and GERD patients highlighted significantly higher expression of TPSAB1, the gene that encodes tryptase, in ERD patients compared with HCs, and the common mast cell surface markers KIT, CD34, VCAM1, and CD16 in BE patients compared with HCs (Figure 7B) (24, 25). The gene discussed is TPSAB1; the disease is gastroesophageal reflux disease.