DESeq2 analysis between healthy controls and GERD patients highlighted significantly higher expression of TPSAB1, the gene that encodes tryptase, in ERD patients compared with HCs, and the common mast cell surface markers KIT, CD34, VCAM1, and CD16 in BE patients compared with HCs (Figure 7B) (24, 25). Here, VCAM1 is linked to gastroesophageal reflux disease.