LGALS9 and hereditary clear cell renal cell carcinoma: The Gal-9/TIM-3 pathway is functional in a wide range of human cancer cells (34), and Gal-9 expression is essentially associated with poor prognostic in many cancers such as renal cell carcinoma or in acute myeloid leukaemia, gastric carcinoma, and pancreatic ductal adenocarcinoma (35, 36).