Similarly, addition of deucravacitinib, a selective tyrosine kinase 2 (TYK2) inhibitor, but not addition of placebo to standard therapy was recently shown to reduce serum levels of BAFF, CCL8, and CXCL10 in patients with active SLE in the phase II PAISLEY (NCT03252587) trial (36, 37). Here, CCL8 is linked to systemic lupus erythematosus.