Additionally, results from macrophage adoptive transfer experiments demonstrated that implantation of C5aR−/− BMDMs or PMX-53-treated WT BMDMs markedly enhanced the activity of tumor-infiltrating CD8+ T cells, while transfer of WT BMDMs significantly suppressed CD8+ T cell activity (Figures S5E and S5F). The gene discussed is C5AR1; the disease is neoplasm.