IL‐6, closely connected with STAT3 pathway, not only upregulates miR‐25‐3p through STAT3/c‐MYC signaling and targets 3′UTR to downregulate PTPRO expression in HCC monocytes, thus promoting PD‐L1 expression in macrophages to magnify T‐cell exhaustion in HCC, but also controls PTPRO expression through IFN‐γ‐dependent mechanism.79 This evidence concerns the gene PTPRO and hepatocellular carcinoma.