Moreover, TREM‐1 TAMs are abundant in hypoxic tissues of HCC, especially in advanced stage and impair CD8+T‐cell function, connected with poor prognosis, because TREM‐1+ TAMs increase chemokine (CC motif) ligand 20 expression through the extracellular signal‐regulated kinase/NF‐κβ pathway and recruit CCR6+Foxp3+Treg, causing immunosuppression.20 Here, NFKB1 is linked to hepatocellular carcinoma.