B7‐H3, a co‐stimulatory molecule involved in the regulation of non‐immune functions, favors PMA‐induced differentiation of THP‐1 cells to the M2 phenotype when overexpressing in HCC, and partial blockade of the STAT3 signaling pathway may inhibit the elevation of B7‐H3 expression on THP‐1 cells.56 Here, STAT3 is linked to hepatocellular carcinoma.