After THP‐1‐derived macrophages (THP‐1‐M) are incubated with 50% HCC‐TCM, M2‐type macrophage markers CD163, IL‐10, and CCR2 are upregulated, and further studies reveal that HCC‐TCM promotes M2 polarization through Wnt2b/β‐catenin signaling, inducing HCC to undergo EMT facilitating proliferation and migration.110. Here, CCR2 is linked to hepatocellular carcinoma.