Orthotopically inoculated hepatic Hepa1‐6 tumors in mice are accelerated by myeloid‐specific NOTCH blockade by conditional disruption of recombination signal binding protein Jκ (RBPj cKO), and NOTCH signaling is negatively correlated with WNT activation in CD68+ macrophages in patient‐derived HCC biopsies, while positively relevant to advanced HCC stages.16 This evidence concerns the gene CD68 and hepatocellular carcinoma.