Another study finds that nuclear accumulation of β‐catenin is positively correlated with CD68 TAM in biopsies from HCC patients; in addition to β‐catenin, levels of Axin2 and c‐Myc are increased in M2, and Wnt/β‐catenin activation stimulates M2 macrophage polarization via c‐Myc.114. This evidence concerns the gene CD68 and hepatocellular carcinoma.