In H22 and PDX mice model of HCC, PLX3397 further enhances CD8 T‐cell infiltration and activates intracellular immune responses by inhibiting the CSF1/CSF1R pathway in TAMs and reducing TAMs recruitment and M2 polarization, which is more effective and comprehensive to conquer sorafenib resistance in synergy with alleviating hypoxia.39 This evidence concerns the gene CD8A and hepatocellular carcinoma.