The tumor microenvironment assists Nogo‐B expression on macrophages to promote TAMs M2 polarization through initiating the Yap/Taz pathway, and verteporfin, an inhibitor of Yap, blocks Nogo‐B‐Yap/Taz‐mediated M2 polarization to inhibit HCC progression.92 This evidence concerns the gene RTN4 and hepatocellular carcinoma.