The infiltration level of M2 polarized macrophages is elevated in patients with hepatocellular carcinoma, and M2 can secrete IL‐6, VEGF, matrix metalloprotease (MMP)‐9, GM‐colony‐stimulating factor (CSF), IL‐10, and monocyte chemoattractant protein‐1 (MCP‐1).12 This evidence concerns the gene MMP9 and hepatocellular carcinoma.