PRKAA1 and glioblastoma: A reduction of AMPK as a result of AMPKα1 siRNA expression or treatment of a selective AMPK inhibitor compound C significantly diminished S/G deprivation-induced HIF-1α stability (Fig. 5F) and expression (Fig. 5G and Fig. S5B of the SI) and its transcriptional activity (Fig. 5H and Fig. S5D of the SI) in GBM cells.