As shown, ACBD3 had an accurate diagnostic value for 17 kinds of cancers, including CHOL (AUC = 0.990), LIHC (AUC = 0.863), STAD (AUC = 0.902), PAAD (AUC = 0.756), ESCA (AUC = 0.883), esophagus adenocarcinoma (ESAD) (AUC = 0.901), esophagus squamous cell carcinoma (ESCC) (AUC = 0.841), BRCA (AUC = 0.805), KICH (AUC = 0.895), Lung cancer (LUADLUSC) (AUC = 0.726), LUSC (AUC = 0.717), LUAD (AUC = 0.741), SARC (AUC = 0.930), PCPG (AUC = 0.739), GBM (AUC = 0.787), Glioma (GBMLGG) (AUC = 0.708), and Oral squamous cell carcinoma (OSCC) (AUC = 0.701) (Fig. 6). This evidence concerns the gene ACBD3 and oral cavity squamous cell carcinoma.