Desmin, β-catenin, cytokeratin 7 (CK7), cytokeratin 20 (CK20), smooth muscle actin (SMA), epithelial membrane antigen (EMA), S100 protein, melanoma antigen (melan A), and human melanoma black (HMB45) were all negative precluding other diagnosis. The gene discussed is MUC1; the disease is melanoma.