The AUC values obtained were 0.965(0.932–0.100), 0.619(0.550–0.687), 0.684(0.604–0.764), 0.906(0.855–0.957), 0.779(0.706–0.852), and 0.805(0.744–0.866), for nomogram, age, CD117, P2X3R, NGF, and TrkA, respectively, indicating that the presence of these factors offers clinical value as prognostic indicators (Fig. 6).The above genes are various genes with increased expression levels in interstitial cystitis tissue immunohistochemistry, and their amounts can be used to evaluate the severity of interstitial cystitis and judge the treatment effect. Here, NGF is linked to interstitial cystitis.