Research into NPC1 in viral infection could lead to new broad-spectrum antiviral strategies for treating many enveloped virus infections by inhibiting cholesterol biosynthesis or uptake, stimulating cholesterol storage, and preventing cholesterol from being trafficked to the PM by modulating the function of cholesterol transfer proteins and suppressing, NPC1 results in systemic antiviral action, suggesting a novel treatment approach against SARS-CoV-2 and other emerging viruses. Here, NPC1 is linked to viral infectious disease.