A study that focused on IL-6 as a predictor of intra-abdominal septic complications (AL, abscess, fistula) in 118 patients with only Crohn’s disease found IL-6 as a significant predictor of POC on POD1, POD3 and POD5 (p < 0.001 for all, AUC 0.71, 0.86, 0.82), and 45% of patients had anti-inflammatory treatment [40]. This evidence concerns the gene IL6 and Crohn disease.