However, in AD OM cells the upregulation of genes associated with the immune response and interferon-mediated signaling after infection with WT-SARS-CoV-2 were less drastic, and only a few genes were observed in the top 20 significant DEG when compared to mock-treated AD OM-ALI cells, including CXCL10 (fc = 2,8), IFI44L (fc = 2,4), RSAD2 (fc = 1,9), IFI6 (fc = 1,3), IFIT1 (fc = 1,3), and OASL (fc = 1,32). Here, IFIT1 is linked to Alzheimer disease.