Based on the log2-fold change, the five most upregulated genes in AD individuals are TUBBP5 (Tubulin beta pseudogene 5), NOS2 (Nitric Oxide Synthase 2), UGT2A2 (UDP Glucuronosyltransferase Family 2 Member A2), NTF3 (Neurotrophin 3), and KCNJ1 (Potassium Voltage-Gated Channel Subfamily J Member 1), while POSTN (Periostin), FN1 (Fibronectin 1), NNMT (Nicotinamide N-Methyltransferase), PAMR1 (Peptidase Domain Containing Associated with Muscle Regeneration 1), and COL4A1 (Collagen Type IV Alpha 1 Chain) are the five most downregulated genes. The gene discussed is POSTN; the disease is Alzheimer disease.