Furthermore, we found AD-associated upstream regulators including ZEB1 (Zinc Finger E-Box Binding Homeobox), TGFB1 (Transforming Growth Factor Beta 1), and TNF (Tumor Necrosis Factor) that are inhibited and NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1), and various EFNA (ephrin A’s) activated in mock AD cells. The gene discussed is TNF; the disease is Alzheimer disease.