Simple regression revealed that Asprosin, NT-ProBNP, TC, TG, HDL-c, LDL-c, ApoA1, Apo B, BUN, Cr, FBG, HbA1C, LVEF, IVS, LVPW, LAD, LVEDD, gender, age, no CAD and no DM were the influential HF factors, with statistically significant differences. The gene discussed is NPPB; the disease is hydrops fetalis.