In this study, 25.3% of our patients had non-NET lesions, including hyperplastic polyps, fundic gland polyps, inflammatory polyps, and gastric xanthomatosis, suggesting that gastrin may play a trophic role on gastric mucosa [22], and we need to carefully distinguish these nonendocrine lesions from gastric NETs in clinical practice. This evidence concerns the gene GAST and hyperplastic polyp.