Univariate and Multivariate Cox regression analysis showed that DPH2 was a significant independent prognostic factor in both the TCGA-LIHC (Fig. S7A, D) and ICGC-LIHC-JP (Fig. S7C, F) datasets, but nor significant in the NODE-HCC dataset (Fig. S7B, E). The gene discussed is DPH2; the disease is hepatocellular carcinoma.