CD8A and neoplasm: Analysis of anti-tumor immune pathway activation showed that the high-risk group elevated activation levels in pathway associated with the Release of cancer cell antigens, CD8 T cell recruiting, Neutrophil recruiting, TH17 cell recruiting, and MDSC recruiting pathways in steps 1 and 4, while the Infiltration of immune cells into tumors, Recognition of cancer cells by T cells, Killing of cancer cells in steps 5, 6, 7 were significantly activated in the low-risk group (Fig. 6D).