NCOA4 and focal segmental glomerulosclerosis: Western blot results showed that the LC3II/LC3I ratio was increased and the level of NCOA4 was increased in the renal tissue of FSGS rats, while the content of FTH1 was significantly decreased (Fig. 6), indicating that ferritinophagy was activated in the renal tissue of FSGS rats and may mediate the occurrence of ferroptosis.