Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that binds to FTH1 and delivers it to lysosomes for autophagic degradation, thereby supplementing the abundance of intracellular iron during iron deficiency, further inducing the Fenton response and ferroptosis in a process known as ferritinophagy21. The gene discussed is NCOA4; the disease is Iron deficiency anemia.