IVW-MR analysis results showed that the positive relationship between the expression of HMGCR and the risk of erectile dysfunction (odds ratio [OR] = 1.27, 95% confidence interval [CI] 1.03–1.57; p = 0.028), suggesting that lower HMGCR expression reduced the risk of erectile dysfunction (Fig. 2 and Table 2). The gene discussed is HMGCR; the disease is erectile dysfunction.