PEX3 and Familial prostate cancer: PC3-LN4 prostate cancer cells lacking PIM1, which display higher GSK3β activation, show a significant decrease in genes linked to peroxisomal biogenesis (peroxisomal biogenesis factor 3 and 5; PEX3 and PEX5) and LD growth (Tip47) (Fig. 3A, B).