GTF2I and Werner syndrome: A study on human induced pluripotent stem cells showed that Gtf2i was responsible for 10–20% of the transcriptional dysregulation in pathways related to pathologies related to Williams syndrome (WS) and the 7Dup autism spectrum disorder19, both involved with altered expression of GTF2I. We recently studied the role of Gtf2i in post-natal excitatory neurons by deleting it using viral gene-editing techniques.