RB1 and urinary bladder carcinoma: Top twenty most overrepresented Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of differentially expressed genes are listed in Fig. 3D. Interestingly, among the 7 genes related to bladder cancer there are several genes associated with cell cycle, including Nras, Myc, Rps6ka5, Rb1, and E2f2.