A ~ threefold increase of CD8 + T cells was also seen (Fig. 3D and E, 1.17 ± 0.25% positive area per high power field in Apobec1 KO AKI vs. 0.46 ± 0.07% positive area per high power field in WT AKI, p < 0.005, one way ANOVA). The gene discussed is APOBEC1; the disease is acute kidney injury.