Surprisingly, we found that KRD score was also strongly correlated with the IC50s of VEGF targeted drugs so that this model was able to predict the response to commonly used chemotherapy drugs in colon cancer including 5-Fluorouracil, irinotecan and oxaliplatin, which made KRD score a more robust and widely-applicable model in predicting individual response to different anti-tumor drugs. The gene discussed is VEGFA; the disease is malignant colon neoplasm.