In addition, high PKM2 expression correlated with poor OS and PFS in males (OS: HR = 1.69, p = 6.4e−08; FP: HR = 1.75, p = 3.2e−07), AJCC (American joint committee on cancer)_T1 patients (OS: HR = 2.03, p = 1.8e−05; FP: HR = 3.08, p = 4.8e−07), AJCC_T2 patients (OS: H R = 1.31, p = 0.025; FP: HR = 1.46, p = 0.0054), AJCC_N0 patients (OS: HR = 1.47, p = 0.00095; FP: HR = 1.53, p = 0.0022), and patients with a history of smoking (OS: HR = 1.72, p = 4.6e−07; FP: HR = 1.97, p = 4.4e−08). The gene discussed is PKM; the disease is cancer.