PKM and head and neck squamous cell carcinoma: In the GEPIA database, high expression of PKM2 was associated with worse OS in CESC, head and neck squamous cell carcinoma (HNSC), acute myeloid leukemia (LAML), LIHC, LUAD, mesothelioma (MESO), PAAD, and uveal melanoma (UVM), but was associated with a better OS in KIRC (Fig. 2A; Table S1).