PKM and lung carcinoma: The results of gene chip-based data showed that high expression of PKM2 was associated with poor OS (HR = 1.56, p = 3e−13), the first progression (FP, HR = 1.97, p = 5.9e−15), and post progression survival (PPS, HR = 1.3, p = 0.041) in lung cancer patients (Fig. 4A).