CD8A and Behcet disease: In BD, the few available studies reported either no difference in the CD8+ compartment in respect to healthy controls33; or a general decrement in the cytotoxic T cells compartment34,35, a decrease in replicating/proliferating (CD71+) cells36, and an increase in proportions of late-differentiated cells (CD28−CD27−) associated both, with age, and with recurrence of illness episodes37.