Higher OPG expression from CRC cells (HCT116-OPG or SW480-EV) suppressed the migration of activated dTHP-1 cells, whereas a low or no OPG environment (HCT116-EV or SW480 OPG-KO) promoted dTHP-1 migration (Fig. 3B). This evidence concerns the gene TNFRSF11B and colorectal carcinoma.