Notably, we observed a number of incompletely penetrant developmental abnormalities in the Arrdc3−/− pups (Fig. 3C), including: underdeveloped eyes (also seen in some Arrdc3+/− animals) (Fig. 3C, D), external and internal haemorrhaging, manifesting, for example, as small areas of haemorrhage on the surface of the thymus (Fig. 3C, F), liver discolouration (Fig. 3C), and one Arrdc3−/− animal presented with an omphalocele (Fig. 3C, E). Here, ARRDC3 is linked to omphalocele.