Synthetic sphingolipids have been shown to activate PP2A and kill glycolysis-dependent cancer cells in part by triggering the internalization of nutrient transporters and in part by mislocalizing PI(3,5)P2 generation by the lipid kinase PIKfyve which triggered cytosolic vacuolization and blocked lysosomal fusion28. The gene discussed is PIKFYVE; the disease is cancer.