Collectively, this study was the first to identify the biological roles of circMAML3, miR-665 and MAPK8IP2 in prostate cancer, which clearly demonstrated that circMAML3 and MAPK8IP2 play an oncogenic role in prostate cancer, and miR-665 inhibits the progression of PCa, and it was confirmed that circMAML3 promotes the progression of PCa by targeting miR-665 to upregulate the expression of MAPK8IP2 (Fig. 9J). The gene discussed is MAPK8IP2; the disease is Familial prostate cancer.