miR-665 targets TRIM8 to regulate the Wnt5a/β-Catenin and Caspase-3 signaling pathways in lung squamous carcinoma to promote cell proliferation and inhibit apoptosis [33]; miR-665 is associated with poor prognosis and promotes metastasis by targeting NR4A3 in breast cancer [34]. This evidence concerns the gene TRIM8 and breast cancer.