Given that both flow cytometry and scRNA-seq results indicated the involvement of ILC3-like cells in the pathogenesis of PF, we next depleted ILC3s by knocking out Rorc expression from Ifngr1-/-Rag2-/- mice, to validate the role of ILC3-like cells in PF. The gene discussed is IFNGR1; the disease is pemphigus foliaceus.