Activating mutations of the serine-threonine kinases NRAS (mutNRAS) or BRAF (mutBRAF) are key drivers of uncontrolled MM growth through constitutive activation of Mitogen-Activated Protein Kinase (MAPK) pathways RAF-MEK-ERK and PI3K-AKT-mTOR [3–5]. This evidence concerns the gene BRAF and Miyoshi myopathy.