PRIMA1 and cancer: All three drugs used in this study aiming to restore p53 wt-function (COTI-2, PEITC, PRIMA1-Met) have proven cytotoxic effects on various cancer types beyond p53 reactivation, mostly due to reactive oxygen (ROS) formation inducing oxidative stress [18, 54–56], which may contribute to lipid peroxidation, and thus, to ferroptosis [57].