RTN4R and brain infarction: We also revealed that LOTUS suppressed not only Nogo–NgR1 binding but also NgR1 binding to all ligands, including MAIs and CSPGs [19], and that it strongly promoted neuronal regeneration and functional recovery in mouse models of spinal cord injury [20–22] and cerebral infarction [23] and in a rat model of unilateral pyramidotomy [24].