Figure 5A, 5C shows the differences in the expression levels of HSP90AA1, CEBPA, and FOXO1 between the CAD and control groups in the GSE12288 and GES71226 datasets. Receiver operating characteristic (ROC) curves were used to detect the diagnostic value of three hub genes for CAD in two datasets (Figure 5B, 5D). HSP90AA1 (area under the curve (AUC), 0.889), CEBPA (AUC, 1.000), and FOXO1 (AUC, 1.000) were detected in GSE71226 with high accuracy. This evidence concerns the gene HSP90AA1 and coronary artery disorder.