MSLN and pleural mesothelioma: A meta-analysis of 28 studies by Cuiet al. [17] demonstrated that serum mesothelin had a pooled sensitivity and specificity of 61% and 87%, respectively, to predict pleural mesothelioma, similar to results from this trial (sensitivity of 73% and specificity of 78% to predict pleural mesothelioma), too low to have utility as a stand-alone diagnostic test (supplementary table S9a).