MSLN and pleural mesothelioma: Using the cut-off at 2.0 nmol·L−1 serum mesothelin had a sensitivity of 73%, specificity of 78%, PPV of 82%, NPV of 69% and AUC of 0.83 for predicting the diagnosis of pleural mesothelioma in the entire cohort (see supplementary tables S9a and b and S12 for full details).