HHIP and chronic obstructive pulmonary disease: In terms of shared genetic risk factors, beyond sharedspecific loci for smoking such as the 15q25.1 locus [27], a study performing partitioned genetic correlation analysis demonstratedgenetic correlations between COPD and CVD traits, notably in histone markers (h3k9ac,h3k4me3), which play a central role in arterial pressure and bronchial cell development[27, 28].Genes such as HHIP and EEFSEC are known to be associatedwith lung development signalling pathway and translation factors necessary for proteinsynthesis associated with COPD and cardiovascular events [27].