Four of thesignals, rs7652391 (nearest gene MECOM), rs9431040(HLX), rs62018863 (TMEM114) and rs185937162(HLA-B), have not been described in association with lung functionbefore, demonstrating the utility of using different lung function phenotypes in GWAS.Genetic factors associated with PRISm are strongly correlated with risk of both otherlung diseases and extrapulmonary comorbidity. This evidence concerns the gene TMEM114 and glycogen storage disease VI.