Apart from VEGF, IL-12p70, IL-13, IL-10, IL-7and M-CSF, the other 35 cytokines (e.g., GRO-α, Trail, MIG, IL -17) did not show any association with the risk of CRC in either IVW primary MR analysis or in other secondary analyses (Fig 2). This evidence concerns the gene IL13 and colorectal carcinoma.