The idea that PRRSV PLP2’s DUB function may have a more direct role in virus infection, besides having innate immune evasive activity, is supported by recent evidence showing that nsp2TF, the -2 ribosomal frameshift product of nsp2 which also contains the PLP2 protease [12] co-localizes with PRRSV membrane (M) and envelope glycoprotein (GP5) heterodimers. Here, ZUP1 is linked to viral infectious disease.