The consequences of PSIS are a series of anterior pituitary deficiencies including growth hormone (GH) deficiency that may be isolated or associated with other hormonal deficiencies including thyroid-stimulating hormone (TSH), adrenocorticotropin (ACTH) and/or luteinising hormone/follicle stimulating hormone (hypogonadotropic hypogonadism, HH). This evidence concerns the gene POMC and hypogonadotropic hypogonadism.